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Welcome to the National Academies of Sciences, Medicine, and Engineering study on Grand Challenges for Environmental Engineering and Science in the 21st Century. Environmental challenges continue to multiply as the global population expands toward 10 billion people by 2050 and as demands for clean water, food, and energy rise, all in the context of global climate change. This study will bring together experts in a wide range of fields who, with input from the scientific community and the broader public, will identify the biggest challenges that environmental engineers and scientists will need to address over the next several decades. The study also will describe how the field—and colleges and universities—might evolve to better address those challenges. The study is modeled, in part, on the NAE Grand Challenges in Engineering.