Emerging Advances in Artificial Intelligence for Environmental Health Research and Decisions: A Workshop
June 6-7, 2019
NAS Building | 2101 Constitution Avenue NW, Washington, DC 20418
How similar are the cells within a particular tissue? New single cell and single molecule analysis tools promise insight on the differences in function between individual cells and molecules, how cells interact as components of a complex system, and how these interactions may change with age, disease, and exposure to environmental stressors.
Join a free workshop to explore this rapidly evolving field of study, review the use of single cell and single molecule analysis tools in environmental health studies, and investigate how to make the data generated most useful to the biomedical and public health fields and to regulatory decision makers.
The National Academies’ Standing Committee on Use of Emerging Science for Environmental Health Decisions (ESEHD) examines and discusses issues on the use of new science, tools, and research methodologies for environmental health decisions. Workshops convened by the ESEHD committee provide a public venue for communication among government, industry, environmental groups, and the academic community about scientific discoveries and advances in methods and approaches that can be used in the identification, quantification, and control of environmental impacts on human health. The ESEHD committee is organized under the auspices of Board on Life Sciences and the Board on Environmental Studies and Toxicology of the National Academies of Sciences, Engineering, and Medicine, and sponsored by the National Institute of Environmental Health Sciences.
- Toward Understanding the Interplay of Environmental Stressors, Infectious Disease, and Human Health (January 15-16, 2019)
- Informing Environmental Health Decisions through Data Integration (February 20-21, 2018)
- The Promise of Genome Editing Tools to Advance Environmental Health Research (January 10-11, 2018)
- Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision Making (November 20-21, 2017)
- Causal Understanding & Risk-Based Decision Making (March 6-7, 2017)
- Personal Environmental Exposure Measurements (November 16-17, 2016)
- Interindividual Variability & Decision Making (September 30-October 1, 2015)
- Microbiome II (January 14 – 15, 2016)
- Metabolomics & the Exposome (May 28 – 29, 2015)
- Modeling the Health Risks of Climate Change (November 3-4, 2014)
- Tissue Chips (July 21-22, 2014)
- Integrating Environmental Health Data (January 10-11, 2013)
- Genomic Plasticity (October 4-5, 2012)
- Systems Biology-Informed Risk Assessment (June 14-15, 2012)
- Individual Variability (April 18-19, 2012)
- Individual Exposomes (December 8-9, 2011)
- Green Chemistry (September 20-21, 2011)
- Mixtures & Cumulative Risk Assessment (July 27-28, 2011)
- The Microbiome (April 27-28, 2011)
- Early Indicators of Disease (October 14-15, 2010)
- Stem Cells (June 3-4, 2010)
- The Exposome (February 25-26, 2010)
- Computational Toxicology (September 21-22, 2009)
- Epigenetics (July 30-31, 2009)
Proceedings & Summaries
- Informing Environmental Health Decisions through Data Integration (2018)
- The Promise of Genome Editing Tools to Advance Environmental Health Research (2018)
- Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision Making (2017)
- Advances in Causal Understanding for Human Health Risk-Based Decision-Making (2018)
- Personal Environmental Exposure Measurements (2017)
- Interindividual Variability & Decision Making (2016)
- Microbiome II (2016)
- Metabolomics & the Exposome (2016)
- Modeling the Health Risks of Climate Change (2015)
- Tissue Chips (2014)
- Systems Biology-Informed Risk Assessment (2012)
- Individual Variability (2012)
- Individual Exposomes (2012)
- Green Chemistry (2011)
- Mixtures and Cumulative Risk Assessment (2011)
- The Microbiome (2011)
- Early Indicators of Disease (2010)
- Stem Cells (2010)
- The Exposome (2010)
- Computational Toxicology (2009)
- Epigenetics (2009)
Melissa Perry (Co-chair)
The George Washington University
Melissa Perry, ScD, MHS, (Co-chair) is Professor and Chair of the Department of Environmental and Occupational Health in the Milken Institute School of Public Health at the George Washington University. Before joining the George Washington University, she spent 13 years on the Harvard School of Public Health’s Department of Environmental Health faculty. She received her BA from the University of Vermont, and her MHS and ScD from The Johns Hopkins University School of Hygiene and Public Health. Dr. Perry’s research focuses on health effects of pesticides; agricultural injuries and exposures; and preventive interventions in workplaces. She is the Chair of the Board of Scientific Counselors for the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry of the Centers for Disease Control and Prevention, and she has been a member of the board since 2014. Dr. Perry was elected to be a Fellow of the Collegium Ramazzini in 2014, and she is a member of the Technical Advisory Board for the Center for Construction Research and Training (CPWR). She served as President of the American College of Epidemiology in 2014-15. She was previously a standing member of the National Institute for Occupational Safety and Health research grant review panel, and she served as an associate editor of the journal Reproductive Toxicology. Dr. Perry has authored over 100 peer-reviewed articles and is currently collaborating on occupational and environmental health projects throughout the world.
Kim Boekelheide (Co-chair)
Kim Boekelheide, MD, PhD, (Co-chair) is Professor of Pathology and Laboratory Medicine at the Brown University School of Medicine. He received his B.A. from Harvard University, and M.D. and Ph.D. from Duke University. His research examines fundamental molecular mechanisms by which environmental and occupational toxicants induce cellular injury and male reproductive effects. Current projects include the development of novel in vitro approaches to safety assessment, use of xenotransplantation approaches for human-relevant toxicity testing, and the discovery of sperm molecular biomarkers that reflect testicular injury. He is Director of the Brown University Superfund Research Program and the Brown University Center to Advance Predictive Biology. His research has been continuously funded by the National Institute of Environmental Health Sciences since 1985 and he has received several awards including a Burroughs Wellcome Toxicology Scholar Award (1994-1999), and the Lifetime Achievement Award (2015) from the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology.
Lesa L. Aylward
Summit Toxicology, LLP
Lesa L. Aylward, PhD, is an Honorary Associate Professor with a joint appointment between Queensland Children’s Medical Research Institute and the National Research Center for Environmental Toxicology (Entox) and a Principal at Summit Toxicology, LLP. Dr Aylward’s research interests include the development and application of toxicokinetic models and the use of biomonitoring for tracking exposure to chemicals in the environment, foods, and consumer products. She has published extensively on the development of tools for the interpretation of biomonitoring data in a risk assessment context and the use of biomonitoring as an exposure assessment tool in epidemiological studies. Her current research interests include evaluation of the sources of and factors influencing inter- and intra-individual variation in chemical biomarker concentrations with a focus on the design and implementation of biomonitoring for exposure characterization in epidemiological studies. She has several current collaborations with Entox researchers on the use of human biomonitoring to characterize chemical exposures in the Australian general population and in occupationally exposed groups.
Texas A&M University
Weihsueh Chiu, PhD, is a professor in the Department of Veterinary Integrative Biosciences at the Texas A&M University. His research focuses on the development of quantitative, data-driven approaches for understanding and predicting the human health effects of environmental chemicals. Specifically, his research applies computational and statistical methods to transform data into knowledge used to protect public health. He also has an interest in approaches to estimate the variability in individual susceptibility to environmental exposures, so as to better protect sensitive subpopulations.
Michigan State University
Kevin C. Elliott, PhD, is an Associate Professor at Michigan State University with joint appointments in Lyman Briggs College, the Department of Fisheries and Wildlife, and the Department of Philosophy. He received his PhD in History and Philosophy of Science from the University of Notre Dame. His research lies at the intersection of the philosophy of science and practical ethics, with an emphasis on critically examining the ways in which ethical and social values influence science and technology. Much of his work has focused on policy-relevant areas of research on environmental pollution, such as endocrine disruption, nanotoxicology, multiple chemical sensitivity, and hormesis. He has authored more than 50 articles and book chapters and has published two books with Oxford University Press: Is a Little Pollution Good for You? Incorporating Societal Values in Environmental Research (2011) and A Tapestry of Values: An Introduction to Values in Science (2017).
New York Department of Health
Gary Ginsberg, PhD, is Director of the Center for Environmental Health New York State Dept of Health and a lecturer at the Yale School of Public Health. Prior to this he was a toxicologist for the Connecticut Department of Public Health. He serves on a number of national committees including US EPA’s Science Advisory Board (2008-present) and the National Academies’ Biomonitoring committee (2004-2006), USEPA Risk Methods committee which produced Science and Decisions (2006-2008), and Inorganic Arsenic Risk Assessment committee (2012-2015). He also served on USEPA’s Children’s Health Protection Advisory Committee (2004-2009) and has been an external reviewer on a number of USEPA IRIS documents. Dr. Ginsberg has been called on by other federal agencies to provide reviews including OSHA (silica workplace standard), CPSC (cadmium in children’s jewelry) and FDA (dental amalgam). His risk assessments on fish contaminants, synthetic turf fields, acrylamide, cadmium, and assessments pertaining to risks in children and those with genetic polymorphisms have been published in peer reviewed journals. Dr. Ginsberg co-authored a book for the lay public called “What’s Toxic, What’s Not” (Berkeley Books, 2006).
Norbert E. Kaminski
Michigan State University
Norbert E. Kaminski, Ph.D., is the Director of the MSU Institute for Integrative Toxicology and a Professor in the Department of Pharmacology and Toxicology. Dr. Kaminski is a member of the Society of Toxicology and Immunotoxicology Specialty Section, the American Association of Immunologists and the International Cannabinoid Research Society. He served as President of the SOT from 2014-2015. Dr. Kaminski currently serves on the NIEHS National Advisory Environmental Health Sciences Council, and is on the External Advisory Committee of the Oregon State University Superfund Center Grant. Dr. Kaminski was an Associate Editor for the Journal of Pharmacology and Experimental Therapeutics and was also on the editorial board for Toxicological Sciences, International Immunopharmacology, and Nonlinearity in Biology-Toxicology-Medicine. He has served on various scientific advisory committees including the National Academy of Sciences Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, the U.S. Environmental Protection Agency Science Advisory Board for the Dioxin Reassessment Review, the Health Effects Task Group for NSF International, and the National Academy of Sciences Committee to review EPA’s Exposure and Human Health Reassessment of TCDD and Related Compounds. Dr. Kaminski served on the Board of Trustees for the International Life Sciences Institute-Health and Environmental Sciences Institute from 2003 to 2012. Dr. Kaminski is a faculty trainer for the NIEHS training grant.
Margaret R. Karagas
Margaret R. Karagas, Ph.D., is Professor and Department Chair of Epidemiology at the Dartmouth College Geisel School of Medicine, and Director of the Children’s Environmental Health and Disease Prevention Research Center and Center of Molecular Epidemiology at Dartmouth. She also currently leads a project in the Dartmouth Superfund Program. Dr. Karagas’ research encompasses interdisciplinary studies to illuminate the etiology of human cancers, along with adverse pregnancy and children’s health outcomes. Her work seeks to identify emerging environmental exposures, host factors and mechanisms that impact health from infancy to adult life, and to apply novel methods and technologies to understand disease pathogenesis. Among her current investigations are population-based studies of the temporal increases in the incidence rates keratinocyte cancers in the US and the contribution of widespread exposures such as indoor tanning, as well as drinking water contaminants. More recently, she established a cohort of pregnant women and their offspring in New Hampshire to assess the sources and potential health impacts of arsenic and other factors, i.e., on childhood infection, allergy/atopy, growth and neurodevelopment through the Children’s Center. The cohort entails multiple collaborative studies of exposure biomarkers, individual susceptibility, and biological response to environmental agents including the developing microbiome and immune response. Dr. Karagas received her PhD from the University of Washington.
Patrick McMullen, Ph.D., has a keen interest in leveraging high-content biological experiments (gene expression studies, high-throughput screens, imaging, and other sources) into a mechanistic understanding of the underlying biology. His background in molecular biology, engineering and programming has been instrumental in interpreting and communicating complex data problems in diverse applications. He manages a diverse computational biology team that uses modeling and high-content data to deepen our understanding of how chemicals interact with biological systems. His group combines expertise and tools from different disciplines to develop innovative strategies for using large-scale data to solve problems related to chemical and drug safety and efficacy.
Gary Miller, Ph.D., is Professor of Environmental Health Sciences in the Mailman School of Public Health at Columbia University. He completed his doctoral training in Pharmacology and Toxicology and postdoctoral training in Molecular Neuroscience. His research has focused on environmental factors involved in the development of neurodegenerative conditions, such as Parkinson’s disease. His laboratory uses a variety of methods including transgenic mouse production, immunohistochemistry, neurotransmitter transport assays, high-resolution metabolomics, electrochemistry, and behavioral assays. Dr. Miller previously served as Director of the Emory HERCULES center, an NIEHS-funded center focused on the exposome, the environmental analogue to the genome. He also served as Director of Emory’s NIEHS-funded T32 Training Grant in Environmental Health Sciences and Toxicology. Dr. Miller is a Georgia Research Alliance Distinguished Investigator and received the Acheivement Award from the Society of Toxicology. He currently serves as Editor-in-Chief of Toxicological Sciences, the official journal of the Society of Toxicology.
Kristi Pullen Fedinick
Natural Resources Defense Council
Kristi Pullen Fedinick, Ph.D., is a staff scientist in the Health Program at the Natural Resources Defense Council. Kristi Pullen’s decades-long research career includes experience in molecular, structural, and computational biology; biochemistry; and population health. Prior to joining the Health program, she worked as a scientist for the Environmental Law and Policy Center, where she focused on air and drinking-water quality, science communications, and environmental justice. For NRDC, Pullen has worked primarily on high-throughput technologies, predictive toxicology, and chemical-risk assessments. She holds a bachelor’s degree in biochemistry and molecular biology from the University of Maryland, Baltimore County, and a Ph.D. in molecular and cell biology from the University of California, Berkeley. She was a Robert Wood Johnson Foundation Health and Society Scholar at the Harvard School of Public Health. She is based in Washington, D.C.
Reza J. Rasoulpour
Reza J. Rasoulpour, Ph.D., is the Science and Technology Leader for the Developmental and Reproductive Toxicology discipline with the responsibility of regulatory testing, investigational research focusing on mode-of-action and epigenetics, and serves Dow businesses as a technical expert consultant. Reza’s primary research focus has been in leading the epigenetics research program designed to evaluate potential transgenerational epigenetic phenomena and to determine the adequacy of the current regulatory toxicity testing program to detect such effects. Reza has participated and/or organized numerous Society of Toxicology sessions, workshops by NAS and ILSI-HESI, and published several review and position papers on the role of epigenetics in chemical safety assessment. To date, he has authored/coauthored 16 peer-reviewed publications to the scientific literature, as well as authored a book chapter on the topic of male reproductive biology. He also serves Dow as a representative on the ILSI-HESI DART Technical Committee. Reza earned a B.S. from the University of Connecticut in molecular and cellular biology, and his Ph.D. in the laboratory of Kim Boekelheide at Brown University.
Gina M. Solomon
California Environmental Protection Agency
Gina M. Solomon, M.D., M.P.H., is a principal investigator at the Public Health Institute in Oakland, California, and a Clinical Professor of Medicine at the University of California, San Francisco. She served as the Deputy Secretary for Science and Health at the California Environmental Protection Agency from 2012-2017. Dr. Solomon’s work has spanned a wide array of areas, including children’s environmental health, reproductive toxicity, cumulative impacts, and the use of novel data streams to screen chemicals for toxicity. Her work has also focused on exposure science for air pollutants, pesticides, mold, and metals in soil, and on the health effects of climate change. She was involved in the aftermath of Hurricane Katrina, the Gulf oil spill, and the Chevron Richmond explosion and fire, and she successfully spearheaded regulations to improve refinery safety in California. Dr. Solomon has served on multiple boards and committees of the National Academies, the EPA Science Advisory Board, and the National Toxicology Program’s Board of Scientific Counselors. She also serves on the EPA Board of Scientific Counselors Chemical Safety for Sustainability subcommittee. Dr. Solomon received her M.D. from Yale and completed her M.P.H. and her residency and fellowship training in internal medicine and occupational and environmental medicine at Harvard.
Jessica De Mouy
Senior Program Assistant