The National Academies’ Standing Committee on Use of Emerging Science for Environmental Health Decisions was established to facilitate communication among government, industry, environmental groups, and the academic community about scientific advances that may be used in the identification, quantification, and control of environmental impacts on human health.
The committee is composed of the following members:
William H. Farland (Chair)
Colorado State University
University of Washington
George P. Daston
Procter & Gamble Company
Richard A. Denison
Environmental Defense Fund
University of Cincinnati
Mount Desert Island Biological Lab
Johns Hopkins University-Bloomberg School of Public Health
Stephen M. Rappaport
University of California, Berkeley
University of North Carolina, Chapel Hill
Martin L. Stephens
Johns Hopkins University-Bloomberg School of Public Health
Joyce S. Tsuji
Cheryl Lyn Walker
Texas A&M Health Science Center
Robert Wood Johnson Medical School
California Environmental Protection Agency
Committee Member Bios
William H. Farland (Chair) is currently the Senior Vice President for Research and Engagement at Colorado State University in Fort Collins, CO. He is also a Professor in the Department of Environmental and Radiological Health Sciences, School of Veterinary Medicine and Biomedical Sciences at that institution. In 2006, Dr Farland was appointed Deputy Assistant Administrator for Science in the US Environmental Protection Agency’s (EPA) Office of Research and Development (ORD). He had served as the Acting Deputy Assistant Administrator since 2001. In 2003, Dr. Farland was also appointed Chief Scientist in the Office of the Agency Science Advisor. He served as EPA’s Acting Science Advisor throughout 2005. Formerly, he was the Director of the ORD’s National Center for Environmental Assessment (NCEA) which had major responsibility for the conduct of chemical-specific risk assessments in support of EPA regulatory programs, the development of Agency- wide guidance on risk assessment, and the conduct of research to improve risk assessment. Dr. Farland’s 27 year federal career was characterized by a commitment to the development of national and international approaches to the testing and assessment of the fate and effects of environmental agents. Dr. Farland holds a Ph.D. (1976) from UCLA in Cell Biology and Biochemistry. Dr. Farland served on a number of executive- level committees and advisory boards within the Federal government. In 2005-2006, he chaired the Executive Committee of the National Toxicology Program (NTP). He is also a member of the Scientific Advisory Council of the Risk Sciences and Public Policy Institute, Johns Hopkins University School of Hygiene and Public Health, a public member of the American Chemistry Council’s Strategic Science Team for its Long Term Research Initiative (ACC/LRI) and a member of the Programme Advisory Committee for the WHO’s International Programme on Chemical Safety. In 2002, Dr. Farland was recognized by the Society for Risk Analysis with the “Outstanding Risk Practitioner Award,” and in 2005 was appointed as a Fellow of the Society. In 2006, he received a Presidential Rank Award for his service as a federal senior executive. In 2007, he was elected as a Fellow, Academy of Toxicological Sciences. He continues to teach and publish and has been a member of the Editorial Board for Risk Analysis, Environmental Health Perspectives and Chemosphere.
Ann Bostrom is Professor at the Daniel J. Evans School of Public Affairs of the University of Washington. She joined the Evans School faculty in 2007. Dr. Bostrom has research interests in risk perception, communication and management, and in environmental policy and decision making under uncertainty. Her research focuses on mental models of hazardous processes (how people understand and make decisions about risks), and has been funded by the National Science Foundation, National Institutes of Health, and the U.S. Environmental Protection Agency. Current projects investigate seismic risk perceptions and decision making in port systems, warning decisions for extreme weather events, and mental models of climate change. Dr. Bostrom previously served on the faculty at Georgia Tech from 1992 – 2007, most recently as Associate Dean for Research at the Ivan Allen College of Liberal Arts and Professor in the School of Public Policy. Dr. Bostrom co-directed the Decision Risk and Management Science Program at NSF from 1999 – 2001, during which time she organized and presented at national and international meetings on research and science policy. Dr. Bostrom is on the editorial boards of Risk Analysis and the Journal of Risk Research, as is the risk communication area editor for Human and Ecological Risk Assessment and a Fellow of the Society for Risk Analysis. She has authored or contributed to numerous publications, including Risk Communication: A Mental Models Approach, and Risk Assessment, Modeling and Decision Support: Strategic Directions, as well as NRC and EPA Science Advisory Board and Board of Scientific Counselor reports. She recently served on the NRC Committee on Review of the FDA’s Role in Ensuring Safe Food and the NRC Committee on Review of the Tsunami Warning and Forecast System and Overview of the Nation’s Tsunami Preparedness. Dr. Bostrom earned her Ph.D. in policy analysis from Carnegie Mellon University in 1990, and an M.B.A. from Western Washington University.
George P. Daston has been employed at Procter & Gamble Company since 1985, where he is Victor Mills Society Research Fellow. Dr. Daston has spent his entire career in research to understand the effects of exogenous chemicals on biological systems, especially the developing embryo, fetus and child. His research interests include teratogenic mechanisms, in vitro methodologies, and risk assessment. He has published over 100 peer-reviewed articles, reviews and book chapters, and has edited three books. Dr. Daston’s professional activities include serving as Councilor of the Society of Toxicology (2001-03); President (1999-2000) of the Teratology Society; member of the National Academy of Sciences Board on Environmental Studies and Toxicology (1995-98); member of the EPA Board of Scientific Counselors (2002-08); member of the U.S. National Toxicology Program Board of Scientific Counselors (2003-06, Chair in 2006); member of the National Children’s Study Advisory Committee (2003-06); and member of EPA’s Endocrine Disrupter Screening and Testing Advisory Committee (EDSTAC). He has served on several NRC committees, including the Committee on Developmental Toxicology, Committee on Research Opportunities and Priorities for EPA, and the Subcommittee on Arsenic in Drinking Water. Dr. Daston has served on the organizing committees for numerous government and private sector-organized workshops on reproductive toxicity, risk assessment, and non-animal alternatives. He chaired NIEHS/ICCVAM working groups evaluating the state of validation of the Frog Embryo Teratogenesis Assay – Xenopus (FETAX) assay for teratogen screening and receptor binding and transcriptional activation assays for estrogens and androgens. Dr. Daston is Editor-in-Chief of Birth Defects Research: Developmental and Reproductive Toxicology. Dr. Daston is an Adjunct Professor in the Department of Pediatrics and Developmental Biology Program at the University of Cincinnati and Children’s Hospital Research Foundation. Dr. Daston received his Ph.D. from the University of Miami and post-doctoral training at the U.S. EPA’s laboratories in Research Triangle Park, North Carolina.
Richard A. Denison is a senior scientist at the Environmental Defense Fund. Dr. Denison has 25 years of experience in the environmental arena, specializing in chemicals policy and hazard, exposure, and risk assessment and management for industrial chemicals and nanomaterials. He is a member of the NRC Board on Environmental Studies and Toxicology and serves on the Green Ribbon Science Panel for California’s Green Chemistry Initiative. Dr. Denison was a member of the National Pollution Prevention and Toxics Advisory Committee, which advised EPA’s toxics office. Previously, Dr. Denison was an analyst and assistant project director in the Oceans and Environment Program, Office of Technology Assessment, United States Congress. Dr. Denison received his Ph.D. in Molecular Biophysics and Biochemistry from Yale University.
Shuk-mei Ho is the Jacob G. Schmidlapp Chair; Director and Professor of the Department of Environmental Health; Director of the Center for Environmental Genetics; and Co-Leader of the Cincinnati Cancer Consortium, in the University of Cincinnati, College of Medicine. An expert in hormonal carcinogenesis, Dr. Ho’s research focuses on the significance of hormones and endocrine disruptors on carcinogenesis in the prostate, ovary, endometrium and mammary gland. Her research utilizes innovative genomic, epigenomic, proteomic, and bioinformatic approaches for the discovery of diagnostic and prognostic biomarkers, novel signaling pathways, mechanism-based therapeutics and interventions, and translational strategies for predicting patients’ responses. Her current programs center on developmental origins of complex diseases including cancer, effects of cadmium and polyaromatic hydrocarbon, oxidative stress, and inflammation-mediated cellular changes. She has served as the Scientific Counsel Member of the National Toxicology Program between 2001and 2004, President-Elect of the Society of Basic Urological Research in 2005, Integration Panel Member of the Department of Defense Prostate Cancer Program since 2007, and is the recipient of the 2007 Women in Urology Award for Excellence in Urologic Research. She has been invited to chair numerous National Institutes of Health and Department of Defense study sections and strategic committees. Dr. Ho has published over 140 scientific articles in peer-reviewed journals. Her current and past research projects have been continuously funded by the National Science Foundation, National Institutes of Health, American Cancer Society, the Department of Defense, and a number of private foundations.
Carolyn Mattingly received a BA in Art History from Oberlin College. Following her liberal arts education, she attended Tulane University and received a PhD in molecular toxicology. As a graduate student, she investigated the effects of the ubiquitous environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on vertebrate development using zebrafish as model organism. She then pursued postdoctoral training at the Weill Medical College of Cornell University where she investigated the effects of retinoids on differentiation in prostate epithelial cells and mechanisms by which environmental chemicals, including AHR ligands, interfered with retinoid signaling. Since 2001, she has been an Investigator and Director of Bioinformatics at the Mount Desert Island Biological Laboratory (MDIBL) in Salisbury Cove, Maine. At MDIBL, Dr. Mattingly is involved in several collaborative research programs. First, she directs development of the publicly available Comparative Toxicogenomics Database (CTD), which aims to enhance understanding about the etiologies of environmentally influenced diseases. She also conducts a laboratory research program in which she is investigating the effects of low-level exposure to arsenic or TCDD on vertebrate development using zebrafish. Recent studies uncovered novel targets of these chemicals that make significant contributions to understanding the basis of consequent phenotypes.
Ana Navas-Acien is Assistant Professor in the Department of Environmental Health Sciences at Johns Hopkins Bloomberg School of Public Health. She is a physician-epidemiologist with a specialty in preventive medicine and public health, and a long-term interest in the health consequences of widespread environmental exposures. Based on an epidemiologic approach, her research investigates chronic health effects of arsenic, selenium, lead, cadmium, and other trace metals. Dr. Navas-Acien has served as an expert witness to the Baltimore City Council and she has served as a member of the 2010 National Toxicology Program Workshop on the Role of Environmental Chemicals in the Development of Diabetes and Obesity. She earned an MD from the University of Granada School of Medicine in Spain and a PhD in epidemiology from Johns Hopkins School of Public Health.
Stephen M. Rappaport is Professor of Environmental Health at the University of California, Berkeley. He is also the Director and Principal Investigator of the Berkeley Center for Exposure Biology, a multidisciplinary program that brings together Berkeley researchers from Public Health, Chemistry, and Electrical Engineering to develop a new generation of biomarkers and biosensors for environmental epidemiology. He is a pioneer in the emerging field of ‘Exposure Biology’ and a prominent advocate of the concept of the ‘Exposome’ as a new paradigm for environmental health. Much of his research involves the development and application of blood protein adducts as biomarkers of exposure to toxic chemicals arising from inhalation, ingestion, and endogenous processes. This has led to the concept of the concept of the ‘Protein Adductome’, representing signatures of people’s exposures to toxic chemicals. By comparing adductomes across populations, Prof. Rappaport hopes to identify important biomarkers of chronic diseases. He has also used environmental measurements and biomarkers to elucidate the human metabolism of several toxic chemicals, notably benzene, and to quantify interindividual variability in biomarker levels due to genetic, environmental and lifestyle factors. Prof. Rappaport has also published extensively in areas related to the assessment of long-term chemical exposures for purposes of controlling hazards and of investigating exposure-response relationships. He has more than 200 peer-reviewed publications and has collaborated extensively with investigators throughout the world.
Ivan Rusyn is Professor with tenure in the Department of Environmental Sciences and Engineering in the School of Public Health at the University of North Carolina at Chapel Hill. He directs the Laboratory of Environmental Genomics and the Carolina Center for Computational Toxicology in the Gillings School of Global Public Health at UNC. He is a member of the Lineberger Comprehensive Cancer Center, Center for Environmental Health and Susceptibility, Bowles Center for Alcohol Studies, and the Carolina Center for Genome Sciences. Dr. Rusyn served on several committees convened by the National Research Council and the WHO/IARC. Dr. Rusyn’s laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants, the genetic determinants of the susceptibility to toxicant- induced injury, and computational toxicology. His laboratory applies molecular, biochemical, genetic and genomics approaches to understanding the mechanisms of environmental agent-related disease. His studies on health effects of environmental agents resulted in more than 105 peer-reviewed publications. Dr. Rusyn received his M.D. (with honors) from Ukrainian State Medical University in Kiev and his Ph.D. in Toxicology from UNC-Chapel Hill. He also trained at the University of Dusseldorf in Germany and at the Massachusetts Institute of Technology.
Martin L. Stephens is Senior Research Associate at the Johns Hopkins Center for Alternatives to Animal Testing. He coordinates the Center’s activities on evidence-based toxicology. Prior to joining Hopkins in October, 2011, Dr. Stephens was vice president of the Animal Research Issues Section at The Humane Society of the United States. He served on the National Academy of Science’ committee that produced Toxicity Testing in the 21st Century, as well as on the Scientific Advisory Panel of the Institute for In Vitro Sciences, the scientific program committees for the World Congresses on the Use of Animals and Alternatives in the Life Sciences, the ScientificAdvisory Committee on Alternative Toxicological Methods for the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, and committees at the Organization for Economic Cooperation and Development and the U.S. Environmental Protection Agency. He currently serves on the management teams of AltTox and Altweb, websites devoted to alternative methods (replacements, reductions, refinements). Dr. Stephens has extensive experience in animal protection and in vitro testing sciences. He earned a Ph.D. in Biology from the University of Chicago.
Joyce S. Tsuji is a Principal Scientist within the Center for Toxicology and Mechanistic Biology of Exponent’s Health Sciences practice. She is a board-certified toxicologist and a Fellow of the Academy of Toxicological Sciences. Dr. Tsuji specializes in assessing exposure and risks associated with chemicals, and in communication of scientific issues. She has worked on projects in the United States and internationally for industry, trade associations, U.S. EPA and state agencies, the U.S. Department of Justice, the Australian EPA, municipalities, and private citizens. Dr. Tsuji’s experience includes human health and environmental toxicology related to a wide variety of chemicals in the environment as well as in products. She has designed and directed dietary and environmental exposure studies and community programs involving heatlh eeducation and biomonitoring for populations potentially exposed to chemicals in the environment, including soil, water, and food-chain exposures. She has also assessed exposure and health risks associated with chemical exposures from air, foods, medical devices, and a variety of consumer products (e.g., cleaners, air fresheners, cosmetics, paints and coatings, carpets, glues, wood preservatives, building materials, and children’s toys and play equipment), including those containing nonotechnology or nanomaterials. Dr. Tsuji has served on expert panels on toxicology and health risks issues for the National Academy of Sciences/National Research Council (including their Board on Environmental Studies and Toxicology and Committee on Toxicology), Institute of Medicine, and federal and state agencies.
Cheryl Lyn Walker is Director of Texas A&M Health Science Center (TAMHSC) Institute of Biosciences and Technology in Houston and Welch Chair in Chemistry and a joint position as Clinical Professor in the College of Veterinary Medicine & Biomedical Sciences at Texas A&M University. Previously, Dr. Walker was Ruth and Walter Sterling Professor of Carcinogenesis at The University of Texas M.D. Anderson Cancer Center. She earned a Ph.D. in cell biology from Southwestern Medical School. Dr. Walker’s research interests include studying the genetic basis of susceptibility to cancer, specifically examining the interaction of carcinogens with genes during tumor development, characterizing the effects of endocrine disruptors on human health, and developing animal models for human disease. She also studies the molecular mechanisms of kidney, breast and uterine cancers and the effect of hormones of gene expression. She has served on the Board of Scientific Counselors of the National Cancer Institute and the NIEHS National Toxicology Program, and is a past President of the Society of Toxicology.
Helmut Zarbl is Professor of Environmental and Occupational Medicine at the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey (UMDNJ). He is a member of the Environmental & Occupational Health Sciences Institute (EOHSI), a joint Institute of UMDNJ and Rutgers, The State University of New Jersey. He is also the Director of the NIEHS Center for Environmental Exposures and Disease at EOHSI, is the Associate Director for Public Health Science at the Cancer Institute of New Jersey. Previously, he was a member of the Divisions of Human Biology and Public Health Sciences at the Fred Hutchinson Cancer Research Center (FHRCR), where he was Director and a Principal Investigator for the NIEHS sponsored FHFRC/University of Washington Toxicogenomics Research Consortium. Dr. Zarbl’s research has focused largely on toxicogenomics and functional genomics, carcinogenesis, molecular and cellular biology, and toxicology. Specifically this has included work to understand molecular mechanisms of chemical carcinogenesis, chemoprevntion, and the genetic basis for differential susceptibility to mammary carcinogenesis using both animal and in vitro model systems. Recent studies include the role of circadian rhythm in cancer risk and prevention. His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments, and phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants, providing insights into dose and temporal responses, as well as mechanisms of action. Dr. Zarbl is also actively involved in technology development, including his patented work on RNAi and its application to the development of novel platforms for functional genomics (with Engineering Arts, Inc). Dr. Zarbl served on the NRC committee that produced Application of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment. Previously he was an Assistant and Associate Professor at M.I.T. He earned his Ph.D. in Biochemistry from McGill University.
Lauren Zeise Chief, Reproductive and Cancer Hazard Assessment Branch, of the California Environmental Protection Agency’s (Cal/EPA) Office of Environmental Health Hazard Assessment. In that role she oversees a variety of scientific activities concerning risk assessment, including chemical hazard and dose response assessment and development of improved methods for risk assessment. As part of Cal/EPA’s environmental justice work, her group is also developing the Agency’s approach to cumulative impact assessment – for characterizing the impact on communities of multiple sources of pollution and non-chemical stressors in the presence of community vulnerability. Her group works with other departments in California government in operating Biomonitoring California, the state’s biomonitoring program. She co-led the team that developed California’s Green Chemistry Hazard Trait regulation. Dr. Zeise has served on numerous national and international science advisory committees and boards focusing on environmental public health and improving the way chemicals are tested or evaluated for health risk. She has coauthored a number of National Academy of Science (NAS) reports, including “Science and Decisions: Advancing Risk Assessment” (2009), “Toxicity Testing in the 21st Century: A Vision and Strategy” (2007), “Sustainability and the US EPA” (2011), and “Understanding Risk: Informing Decisions in a Democratic Society” (1996). She is currently a member of the NAS committees including the Committee on Use of Emerging Science for Environmental Health Decisions. She is member, fellow, former editor and former councilor of the Society of Risk Analysis and was the 2008 recipient of the Society’s Outstanding Risk Practioner Award. She is a lifetime NAS National Associate. She received her doctorate from Harvard University.