Bioengineered Organotypic Platforms

Bioengineered Organotypic Platforms as Model Systems of Intermediate-level Biological Organization for Environmental Health Studies

Summer 2014

This meeting will explore emerging biological platforms (also called bioengineered organotypic platforms or microphysiological systems) and how these emerging technologies can be applied to environmental health research and regulatory contexts. Advances in nanotechnology, micro-engineering and fluidics, systems biology, and stem cell technology have enabled the development testing platforms that are seeded with multiple cell types, often of human origin, including organ-on-a-chip and more three-dimensional constructs.  These advanced platforms are distinguished from earlier in vitro model systems, such as (two-dimensional) cell culture, tissue explants, and three-dimensional aggregations of cells. Emerging biological platforms may provide a means of addressing the diversity, complexity, and integration of biological responses to environmental health challenges. Potential meeting topics include:

  • Developing biological platforms as a risk assessment tools (i.e. moving complex in vitro systems from use as hazard identification tools to be more broadly applied in risk assessment)
  • Use of biological platforms to identify toxicity (toxicity pathways?) that require multi-tissue or organ integration
  • Application of biological platforms to address issues associated with chronic toxicity