Use of In Utero and Post-Natal Indicators to Predict Health Outcomes Later in Life
October 14-15, 2010
The Washington Club
15 Dupont Circle NW
Washington, DC 20036-1299
- Agenda (PDF)
- Reading List (PDF)
- Speaker and Panelist Bios (PDF)
- Presentations and Audio Recordings
- Newsletter (PDF)
This meeting will provide a brief background on traditional testing strategies used to detect later-life effects following in utero or post-natal stressors. It will also explore the emerging science in this area using two case studies. The first case study is end-point driven and will examine developmental origins of obesity, insulin resistance, and hypertension. The second will explore in utero or post-natal exposure to arsenic and potential indicators that could predict later-life effects. Finally, the meeting will include discussions on implications for using this emerging science for risk assessment or decision-making purposes. Some questions that will be used to guide the meeting include the following:
- What is the range of adult disease states that have developmental origins?
- What are the possible mechanisms for persistent, adult-onset effects associated with developmental exposures?
- What early life biomarkers are available to predict later life disease?
- How good are current animal tests in detecting associations between early life exposures and later life effects?
- Are there shorter-term animal tests or mode-of-action-based in vitro/human biomarker tests that detect early life events and are predictive of later life effects?
- Is our scientific understanding of these processes sufficient to inform weight-of-evidence-based risk assessments and regulatory practices?