The Exposome: A Powerful Approach for Evaluating Environmental Exposures and Their Influences on Human Disease

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February 25-26, 2010

NAS Building, Auditorium

2100 C Street NW

Washington, DC 20001

Recognizing the disparity in current knowledge between genes and environmental exposures, Dr. Christopher P. Wild defined the “exposome,” representing all environmental exposures from conception onwards (including exposures from diet, lifestyle, and endogenous sources) as a quantity of critical interest to disease etiology (Wild, 2005). Dr. Wild argued that if we expect to succeed in identifying the combined effects of genetic and environmental factors on chronic diseases, we must develop 21st-century tools to characterize exposure levels in human populations.

This meeting examined the concept of the exposome and its importance to the etiology of human diseases. In doing so, we considered the roles that epidemiologists and laboratory scientists can play in identifying resources and technologies for elaborating the exposome in human populations.

Wild CP. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology.
Cancer Epidemiol Biomarkers Prev, 2005; 14(8): 1847-50.