Meeting Presentations: Genomic Plasticity

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Speakers from a number of fields participated in discussions and presentations over the course of October’s two-day event on “Exploring Human Genomic Plasticity and Environmental Stressors: Emerging Evidence on Telomeres, Copy Number Variation, and Transposons” in environmental health decisions.

Archived Webcast.  If you did not previously register for the webcast, you will be asked to register before viewing the archived files. Registration is free

**Please note: If you have a disability and need assistance with accessing the content of these PowerPoint presentations, please contact Ayesha Ahmed at sahmed@nas.edu or  (202) 334-1348.

 

Session 1: Workshop Introduction

John Balbus: Opening Remarks (please access archived webcast)

Cheryl Lyn Walker: Introduction to the Standing Committee and Objectives of Today’s Meeting [PDF]

Thea Tlsty: Introduction to Genomic Plasticity [PDF] to be posted soon

 

Session 2: Telomeres/Telomerase

Maria A. Blasco*: Telomeres as Key Modulators of Aging and Longetivity [PDF]

*DISCLOSURE: Dr. Blasco discussed the company Life Length in her presentation.
Life Length is a company founded in September 2010 by Dr. Blasco, Matlin
Associates and the Botín Foundation with the objective of commercializing the
Telomere Analysis Technology (TAT) developed by Dr. Blasco.

Elissa Epel: Lifespan and Psychosocial Factors Associated with Telomere Length [PDF]

 

Environmental Linkages with Telomeres/Telomerase

David P. Gilley: Telomere Disfunction in Breast Differentiation, Aging, and Cancer [PDF]

Dale P. Sandler: Lifestyle and Environmental Factors Associated with Telomere Length [PDF]

 

 Session 1 & 2 panel discussions are available via archived webcast 

Moderator: Shuk-mei Ho

Panelists: Thea Tlsty, Elissa Epel, David P. Gilley, Dale P. Sandler

 

Session 3: Copy Number Variation and Chromothripsis

James R. Lupski: Genomic Disorders, Mechanisms for Copy Number Variation, and CNV in Evolution [PDF]

 

Environmental Linkages with Copy Number Variation

Thomas W. Glover: Experimental Insights into Genetic and Environmental Risk Factors for CNV Formation [PDF]

Joseph R. Shaw: Discovering the Role of Copy Number Variation in Populations [PDF]

Jennifer L. Freeman: Role of Chemical Exposure in Generating  Spontaneous CNVs [PDF]

Randal Johnston: Origins and Consequence of Copy Number Variation in Cancer [PDF]

 

Session 3 panel discussion is available via archived webcast 

Moderator: Helmut Zarbl

Panelists: James R. Lupski, Thomas W. Glover, Joseph R. Shaw, Jennifer L. Freeman, Randal Johnston

 

Session 4: Jumping Genes and Mobile Elements

John V. Moran: Studies of a Human Retrotransposon [PDF]

 

Environmental Linkages with Jumping Genes

Kenneth Ramos: A Story of LINES and the Intersection of Genetic and Epigenetic Mechanisms in Reprogramming the Mammalian Genome by Environmental Injury [PDF]


Session 4 panel discussion is available via archived webcast 

Moderator: Cheryl Lyn Walker

Panelists: John V. Moran, Kenneth Ramos

 

Session 5 panel discussion of Implications and Research Needs is available via Archived Webcast

Moderator: Daniel Shaughnessy

Panelists: Helmut Zarbl, Thomas W. Glover [PDF], George Daston, Thea Tlsty, Laurence H. Baker

 

Closing Comments: Kenneth Ramos Archived Webcast