Meeting Presentations: Individual Variability

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Speakers from a number of fields participated in discussions and presentations over the course of a two-day (April 18-19, 2012) event on “Biological Factors that Underlie Individual Susceptibility to Environmental Stressors and Their Implications for Decision-Making” in environmental health decisions. Here you can find the PowerPoint presentations from each talk in the
Archived Webcast. If you did not previously register for this webcast, you will be asked to register before viewing the archived files. Registration is FREE.**Please note: If you have a disability and need assistance with accessing the content of these PowerPoint presentations, please contact Ayesha Ahmed at or  (202) 334-1348.
 Introduction/Framing of Meeting: William Farland [PDF]

Session 1: Meeting Introduction

Nathaniel Rothman: Characterizations of the Problem: What Do We Know About Individual Variability and Its Contribution to Disease? [PDF]

Claudia S. Miller: Human Variability in Chemical Susceptibility (Intolerance/Sensitvity), Research Findings to Date and Their Implications for Future Study Design [PDF]

Eric Schadt: Technologies to Capture Biological Differences Among Individuals [PDF]


Session 2: Study Designs to Understand the Impact of Biological Variability Among Individuals in Response to Environmental Agents

Fred A. Wright: Quantitative High-Throughput Screening for Chemical Toxicity in Population-Based In Vitro Models [PDF]

John E. (Jef) French: Using Population-Based Animal Models to Explore Individual Variability and Toxicity Recording of this talk available via Archived Webcast

Joel Schwartz: Human Studies that Explore Individual Biological Variability and their Effect on the Susceptibility to Disease [PDF]

Harvey Clewell: Modeling Populations from Data on Individuals [PDF]

Duncan Thomas: Individual Variability in Sensitivity to Environmental Exposures and Its Implications for Risk Assessment [PDF]


Sessions 1 and 2 panel discussions are available via Archived Webcast

Moderators: George Daston

Panelists: Sessions 1 and 2 speakers


Session 3: Using Information on Biological Variability Among Individuals for Public Health Decisions

James (Jim) Kaput: How Findings from Population-Based Studies May Inform Public Health Decisions on the Individual Level [PDF]

Peter Shaw: A Perspective on Pharmacogenetics and Dealing with Emergent Data to Develop Stratified Medicines [PDF]


Session 4: Using New Information on Individual Biological Variability for Environmental Regulatory Decisions

Michael Dourson: How Individual Variability Is Currently Factored Into Risk Assessment/Regulation/Decision Making [PDF]

Weihsueh Chiu: Biological Variability and Improving Environmental Decision-Making [PDF]


Sessions 3 and 4 panel discussions are available via  Archived Webcast

Moderators:  Joyce Tsuji

Panelists: Sessions 3 and 4 speakers


Session 5 panel discussion on Community Perspectives on Bridging the New Science with Decision Making, Including Individual Decision Making is available via Archived Webcast

Session 5 Panel Discussion Questions

Moderators:  Richard Denison

Panelists: Nicholas Ashford, Nsedu Witherspoon, Barbara Biesecker


Session 6: Opportunitites for New Approaches: Implications of New Data to Inform Risk Assessment and Regulatory Decision

Nicholas Ashford: Moving from Risk-Driven Chemicals Policies to Technology-Based Solutions [PDF]


Session 6 panel discussion is available via Archived Webcast

Session 6 Panel Discussion Questions

Moderators:  Ivan Rusyn

Panelists: James (Jim) Kaput, Daniel Axelrad, Weihsueh Chiu, Zachary Pekar


Session 7 Panel Discussion: What Research is Needed to Move Forward in this Area?

Recording of the panel discussion is available via Archived Webcast

Session 7 Panel Discussion Questions

Moderators:  Cheryl Lyn Walker

Panelists: Richard Woychik, Duncan Thomas, John E. (Jef) French, Fred Wright, Barbara Biesecker, Deborah Winn