Interindividual Variability: New Ways to Study and Implications for Decision-Making

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September 30 – October 1, 2015

National Academies of Sciences, Engineering, and Medicine: Keck Center
Room 100
500 5th Street NW
Washington, DC

Discuss on Twitter: #NASvariability

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Within any population, factors such as heritable characteristics, stress, body weight, and genetics can influence the type and degree of response that people may have to environmental stressors.  Accounting for this interindividual variability is a challenge for decision makers tasked with setting chemical safety regulations.

This workshop focused on recent scientific advances that could help elucidate the sources of interindividual variation. Researchers, professionals, and policy experts explored new tools and how they may be used to advance the science behind risk-based decisions.

The workshop included presentations, panel discussions, and breakout sessions on topics such as:

  • in-vitro toxicology methods using highly diverse cell lines;
  • in-vivo methods using highly diverse animal populations;
  • epidemiologic analytical approaches which explore mediators within the causal pathway.

This National Academy of Sciences activity is sponsored by the National Institute of Environmental Health Sciences (NIEHS).