Interindividual Variability: New Ways to Study and Implications for Decision Making: Presentations

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On September 30-October 1, 2015 the Standing Committee on Use of Emerging Science for Environmental Health Decisions convened a 2-day workshop, Interindividual Variability: New Ways to Study and Implications for Decision Making.

Each title links to a PDF of the workshop presentation, unless otherwise noted.

 

Day 1: September 30, 2015

 

The Importance of Understanding Interindividual Variability in Response to Chemical Exposures

—Linda Birnbaum, National Institute of Environmental Health Sciences

 

Introduction: Why Interindividual Variability Matters in Decision Contexts

—Lauren Zeise, California EPA, Office of Environmental Health and Hazard Assessment

 

How Interindividual Variability is Captured in Environmental Regulations

—John Vandenberg, EPA–National Center for Environmental Assessment

 

How Interindividual Variability is Addressed When Considering Pharmaceutical Safety

—Jon Cook, Pfizer

 

How Interindividual Variability is Captured in Occupational Guidelines

—Terry Gordon, American Conference of Governmental Industrial Hygienists Threshold Limit Values Committee

 

SESSION 1: IN VITRO METHODS AND RESOURCES

Moderator: Ivan Rusyn, Texas A&M University

 

1000 Genomes High-Throughput Screening Study

—Fred Wright, North Carolina State University

 

NIH Roadmap Epigenomics Program: Resources, Obstacles, and Opportunities

—John Satterlee, National Institute on Drug Abuse

 

Integrating In Vitro and In Silico Methods to Evaluate Variability

—Barbara Wetmore, The Hamner Institutes for Health Sciences

 

Panel Discussion—How In Vitro Methods and Resources May Improve Risk Decisions (YouTube only)

−John Vandenberg

−Anna Lowit, EPA–Office of Pesticide Programs

−Michael Pacanowski, FDA–Center for Drug Evaluation and Research

−Jon Cook

−Gary Ginsberg, Connecticut Department of Public Health

−Terry Gordon

−Fred Wright

−John Satterlee

−Barbara Whetmore

 

SESSION 2: IN VIVO METHODS

Moderator: Lauren Zeise

 

Collaborative Cross

—David Threadgill, Texas A&M University

 

Diversity Outbred Mice

—Michael Devito, NIEHS–National Toxicology Program Laboratory

 

Panel Discussion—How In Vivo Methods May Improve Risk Decisions (YouTube only)

−John Vandenberg

−Anna Lowit

−Michael Pacanowski

−Jon Cook

−Gary Ginsberg

−Terry Gordon

−David Threadgill

−Michael Devito

Day 2: October 1, 2015

 

SESSION 3: EPIDEMIOLOGIC METHODS

Moderator: John Balbus, National Institute of Environmental Health Sciences

 

Epidemiologic Techniques to Evaluate Factors Associated with Interindividual Variability

—Joel Schwartz, Harvard School of Public Health

 

 

Identification of Molecular Mechanisms that Drive Interindividual Variability Using Mediation Analysis

—Joshua Millstein, Keck School of Medicine of USC

 

Panel Discussion—How New Epidemiology Methods May Improve Risk Decisions (YouTube only)

−John Vandenberg

−Michael Pacanowski

−Jon Cook

−Gary Ginsberg

−Joel Schwartz

−Joshua Millstein

 

 

SESSION 4: IMPLICATIONS OF UNDERSTANDING INTERINDIVIDUAL VARIABILITY

 

Panel Discussion (YouTube only)

Moderator: Gina Solomon, California Environmental Protection Agency

−Kimberly White, American Chemistry Council

−Michael Yudell, Drexel University

−Kristi Pullen, Natural Resources Defense Council

−James C. O’Leary, Genetic Alliance