Reproducibility Issues in Research with Animals and Animal Models

The missing “R”: Reproducibility in a Changing Research Landscape

A workshop of the Roundtable on Science and Welfare in Laboratory Animal Use

National Academy of Sciences, NAS 125
2100 C Street NW, Washington DC
June 4-5, 2014

The ability to reproduce an experiment is one important approach that scientists use to gain confidence in their conclusions.  Studies that show that a number of significant peer-reviewed studies are not reproducible has alarmed the scientific community.  Research that uses animals and animal models seems to be one of the most susceptible to reproducibility issues.

Evidence indicates that there are many factors that may be contributing to scientific irreproducibility, including insufficient reporting of details pertaining to study design and planning; inappropriate interpretation of results; and author, reviewer, and editor abstracted reporting, assessing, and accepting studies for publication.

In this workshop, speakers from around the world will explore the many facets of the issue and potential pathways to reducing the problems.  Audience participation portions of the workshop are designed to facilitate understanding of the issue.

The session will be webcast.  An individually-authored summary of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.


Click here to view the presentations that were given at the Workshop, as well as the video recording of the event.


Click here to view the agenda book from the event.

This workshop was made possible by generous donations from:

Covance Laboratories, Inc., University of Washington, University of Michigan, Massachusetts Institute of Technology, Novartis Corporation, American Veterinary Medical Association, American College of Laboratory Animal Medicine, Massachusetts General Hospital, GlaxoSmithKline, University of California–Davis, University of Illinois, Charles River Laboratories, Bayer Healthcare, Merck, Janssen Pharmaceutical Companies of Johnson and Johnson and the National Academies.

Reproducibility Issues in Research with Animals and Animal Models Workshop Committee

Kent Lloyd, Co-Chair
University of California, Davis
Steven Niemi, Co-Chair
American College of Laboratory Animal Medicine
Bonnie V. Beaver
Texas A&M University
Brian R. Berridge
Pamela Chamberlain
U.S. Food and Drug Administration
Carol Clarke
APHIS – US Department of Agriculture
Margaret S. Landi
Malcolm Macleod
University of Edinburgh, UK
Brian C. Martinson
HealthPartners Institute for Education and Research
Susan Brust Silk
Office of Laboratory Animal Welfare
National Institutes of Health