Neurobiology of Addictive Behaviors

As one of society’s major public health problems, addiction poses a tremendous threat to the health and welfare of individuals, families, communities, and nations.  Despite the significant new information that scientists have gained over the past two decades from preclinical and clinical studies, a great deal remains unknown about addiction-like behaviors.  Even as scientists learn more about the neurobiological underpinnings of addiction, new categories of addictions are being defined and include addictions to prescription medication, food, Internet, gambling, sex, and shopping.

Scientists have gained significant insight into the neurobiological adaptations that underlie addiction-like behaviors from convergent evidence in the fields of neuroscience, genetics, and psychiatry.]  Many of the articles in the issue deal with animal models for the study of the neurobiology of addiction-like behaviors. The issue concludes with important recommendations for members of institutional animal care and use committees (IACUCs) as they consider the multiple facets involved in investigations into the neurobiology of addiction-like behaviors.

Online-only articles
90% Hepatectomy with a Porto-hepatic Shunt in a Canine Model: A Feasibility Study
Shawn Steen, Charles Conway, Catalina Guerra, Hamed Kargozaran, and Singh Gagandeep
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Ferret Thoracic Anatomy by 2-Deoxy-2-(18F)Fluoro-D-Glucose (18F-FDG) Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Imaging
Albert Wu, Huaiyu Zheng, Jennifer Kraenzle, Ashley Biller, Carol D. Vanover, Mary Proctor, Leslie Sherwood, Marlene Steffen, Chin Ng, Daniel J. Mollura, and Colleen B. Jonsson
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Gradual Training of Alpacas to the Confinement of Metabolism Pens Reduces Stress When Normal Excretion Behavior Is Accommodated
Kirrin E. Lund, Shane K. Maloney, John T. B. Milton, and Dominique Blache
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Influence of Animal Species on Secondary Oxidant Activation in Serum Exposed to Singlet Oxygen
Isabelle Lhommeau, Samuel Douillard, Antoine Foursac, Lorena Aillet, Edith Bigot, and Thierry Patrice
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Kinetics of BoHV-1 Dissemination in an in Vitro Culture of Bovine Upper Respiratory Tract Mucosa Explants
Lennert Steukers, Annelies P. Vandekerckhove, Wim Van den Broeck, Sarah Glorieux, and Hans J. Nauwynck
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Mice Anesthesia, Analgesia, and Care, Part I: Anesthetic Considerations in Preclinical Research
Sara Gargiulo, Adelaide Greco, Matteo Gramanzini, Silvia Esposito, Andrea Affuso, Arturo Brunetti, and Giancarlo Vesce
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Mice Anesthesia, Analgesia, and Care, Part II: Special Considerations for Preclinical Imaging Studies
Sara Gargiulo, Adelaide Greco, Matteo Gramanzini, Silvia Esposito, Andrea Affuso, Arturo Brunetti, and Giancarlo Vesce
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The Impact of Transportation on Physiological and Behavioral Parameters in Wistar Rats: Implications for Acclimatization Periods
Johanna W. M. Arts, Klaas Kramer, Saskia S. Arndt, and Frauke Ohl
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Estimation of Individual Rodent Water Consumption from Group Consumption Data for Gestation, Lactation, and Postweaning Life Stages Using Linear Regression Models
Elizabeth J. Slone, Linda K. Teuschler, Laura L. Aume, Michael G. Narotsky, Jane Ellen Simmons, Robert A. Lordo, and Glenn E. Rice
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