Allison Snow: Ecological & Evolutionary Conditions for Gene Flow in Plants
Nora Besansky: Ecological & Evolutionary Conditions for Gene Flow in Mosquitoes
Q&A Scientific Considerations
Francis Macrina: Scientific Integrity
Bruce Jennings: Ethics in Science & Governance of Science
Jesse Kirkpatrick & Andrew Light: Do Gene Drives Present Novel Ethical Considerations?
Q&A Responsible Conduct and Ethics
Diran Makinde: Governance of Biosafety of Biotechnology Research in African Counteries
Wannapa Suwonkerd: Community Influence on Vector Control Research & Governance in Thailand
Norma Padilla: Multi-country Field Trials of Biotechnology in Latin America
Q&A Perspectives on Low & Middle Income Countries
David Wirth: International Mechanisms to Govern Biotechnology
The National Academies of Sciences, Engineering, and Medicine Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct hosted a workshop to explore the science, ethics and governance of gene drive research. The workshop was organized as part of the Committee’s information-gathering process as it prepares its consensus report.
With sessions on the scientific considerations of gene drive research, responsible conduct and ethics, perspectives on opportunities and limitations in low and middle income countries, and scales of governance, this workshop brought together leading researchers and decision makers in the field.
This webinar reviewed the current status of gene drive research and outline next directions for the field. The webinar was an information-gathering meeting for the committee in which the speakers are invited to provide input to the committee.
Presentation by Ethan Bier (1:09)
Q&A with Ethan Bier and Valentino Gantz (39:38)
Ethan Bier, Professor of Biological Sciences, University of California San Diego bio
There are two primary areas of research in Dr. Bier’s lab: 1) developmental patterning, and 2) using Drosophila as model to understand human disease processes. A major goal of the research program is to exploit genome-wide information to understand how gene regulatory networks form and function. One key component of this latter effort is to use Drosophila as a tool for identifying and characterizing the function of human genes and the disease-causing mechanisms of human bacterial pathogens. As one enabling tool in these efforts, he has developed a highly sensitive method for multiplex in situ hybridization, which makes it possible to determine the relative expression patterns of large numbers of genes with great spatial and temporal resolution.
Valentino Gantz, Post Doctoral Researcher, University of California San Diego bio
Dr. Bier is a postdoctoral researcher in the laboratory of Dr. Ethan Bier at UC San Diego. As a doctoral student, Dr. Bier lead the research to develop a mutagenic chain reaction method to copy an engineered gene from one chromosome to its counterpart using CRISPR/Cas9 genome editing system.
This webinar focused on gene drive research in different organisms, including mosquitoes and rodents. The webinar was an information-gathering meeting for the committee in which the speakers were invited to provide input to the committee.
Fred Gould: General Overview
Zachary Adelman: Gene Drives in Mosquitoes
John Godwin: Gene Drives in Rodents + Q&A
The Landscape of Gene Drive Research in Different Organisms – Fred Gould, Professor of Entomology at North Carolina State University bio
Fred Gould is Willian Neal Reynolds Distinguished Professor of Entomology and co-director of the Genetic Engineering and Society program at North Carolina State University. He also is the director of an NSF-IGERT graduate training program “Genetic Engineering and Society: The case of transgenic pests”. Dr. Gould’s research focuses on the ecology and genetics of insect pests in order to better understand natural and human-induced evolution. In addition his work explores the potential for genetically engineering insects to suppress disease and crop loss, as well as to protect endangered species. He assisted in the research and regulations for deploying insecticidal transgenic crops in ways that suppress the evolution of pest resistance. Dr. Gould was elected to the U.S. National Academy of Sciences in 2011 and serves on the National Academies Board on Agriculture and Natural Resources.
Gene Drives in Mosquitoes for Disease Vector Control – Zachary Adelman, Associate Professor of Entomology at Virginia Tech bio
Zachary Adelman is an Associate Professor in the Department of Entomology at Virginia Polytechnic Institute and State University. Dr. Adelman’s research program focuses on viruses and mosquitoes. He seeks to understand, at the molecular and genetic level, how these viruses infect, replicate, and are transmitted by mosquitoes to humans. He also seeks to understand the mosquito immune response to these viruses, as unlike people, mosquitoes do not become ill when infected with these deadly viruses. Only by understanding genetic changes in the mosquito, genetic changes in the virus, as well as the effects of different environmental situations can one truly hope to prevent mosquito-borne viral outbreaks. The long-term application of Adelman’s research is to use this information to design and implement new methods of controlling or preventing mosquito-borne viral disease outbreaks. This includes using genetics to block the mosquito’s ability to transmit viruses, and the development of new diagnostic tools to identify mosquitoes that are more likely to participate in an outbreak. Work in Dr. Adelman’s lab centers around two potential gene drive mechanisms: homing endonucleases and transposable elements. He also studies mosquito-pathogen interactions using a transgenic “sensor” strain of A. aegypti which displays conditional green fluorescence in the eyes under conditions where RNA interference has been compromised.
Gene Drives in Rodents for Invasive Species Control – John Godwin, Associate Professor of Biology at North Carolina State University bio
Dr. John Godwin is an Associate Professor of Biological Sciences at North Carolina State University. Dr. Godwin’s research centers on the study of animal behavior and sex determination with the goal of linking genes to behavioral and sexual phenotypes important for various adaptive challenges including mating successfully and coping with stressors. Research projects in his laboratory focus on fishes, lizards, and mammals, including a study on the neuroendocrinology and functional genomics of sex- and role-change in a coral reef fish; neural and functional genomic bases of anxiety-related behavior and stress responsiveness using domestic and wild-derived zebrafish; and a NSF-funded IGERT program focused on the possibility of genetic approaches to controlling invasive rodents on islands.